The Reds were paired with the Czech club during Friday’s draw in Nyon, Switzerland.
The first leg at Stadion Letna is scheduled to kick off at 5.45pm GMT on Thursday March 7, with the second leg at Anfield set for an 8pm kick-off on Thursday March 14.
Ticket details will be published on Liverpoolfc.com in due course. Both matches will be shown live on TNT Sports in the UK.