Although Phil Parkinson’s side started brightly, the Hammers scored two goals before the break to gain the upper hand.
Relegated from the Premier League last season and favourites for the title, the home side made it 3-0 early in the second half and there was no way back after that as the Reds conceded three more goals.
A dreadful performance and worst defeat under Parkinson.
Here’s how the players rated.
ANTHONY PATTERSON: Made superb early save but will feel he could have done better with some of the goals. 4
ZAK VYNER: Won’t be happy with the first two goals in particular. 4
JOE WORRALL: Came into the side for his debut but the defence couldn’t cope with the Hammers’ strike-force. 4
CALLUM DOYLE: Has had a decent start to the season but it was tough going at the London Stadium. 4
DANNY IMRAY: Wrexham started brightly but the wing-backs were more on the defensive against a quality Hammers side. 4
GEORGE DOBSON: Had a shot cleared off the line in rare Wrexham chance at 1-0 but not a lot went right after that. 4
BEN WHITEMAN: Captain for the night, Whiteman and his midfield were second best in the capital. 4
JACQUES EKOMIE: Just like with Imray, wasn’t able to get forward as much as he has in other games due to the Hammers’ threat. 4
CALLUM O’HARE: Huffed and puffed but the Reds struggled to make an impression when they did get to the final third. 4
LEWIS O’BRIEN: Wrexham struggled to create chances on a night to forget. 4
SAM SMITH: An isolated figure who never got into the game, but Wrexham didn’t help themselves. 4
SUBSTITUTES:
ISSA KABORE: The damage was done when the substitutes came on. 4
DOMINIC HYAM: Left out of the side for the first time this season, the captain was introduced at 4-0. 4
MATTY JAMES: There was no way back when four changes were made it one go. 4
KIEFFER MOORE: It was the same for Moore as Smith as the lone striker. 4