The Bees beat West Ham United 3-0 last time out, while Pep Guardiola’s side drew 3-3 with Everton thanks to a last-minute Jérémy Doku equaliser.
Brentford (4-3-3): Kelleher; Kayode, Ajer, Collins, Hickey; Jensen, Damsgaard, Yarmoliuk; Lewis-Potter, Thiago, Schade
Subs: Valdimarsson, van den Berg, Pinnock, Henderson, Dasilva, Nelson, Ouattara, Janelt, Furo
Manchester City (4-2-3-1): Donnarumma; Nunes, Guéhi, Aké, O’Reilly; Reijnders, Silva; Doku, Cherki, Semenyo; Haaland
Subs: Trafford, Dias, Stones, Marmoush, Kovacic, Nico, Ait-Nouri, Savinho, Foden