But if you are unable to make it to Wembley on Saturday, April 25, you do not have to miss out on the action, with full TV coverage available at home.
Saints are looking to reach a first FA Cup final since 2003, 50 years on from their famous trophy win as a second division side in 1976.
They face a test in Pep Guardiola’s Man City, the current Premier League leaders, but will believe after they knocked out Arsenal in the last round.
Saints beat Arsenal to reach the FA Cup semi-final (Image: PA)
Here is how you can follow all the action at home…
How can I watch it on TV?
The 5.15pm kick-off has been selected for TV broadcasting by the BBC and TNT Sports, and will be shown live on BBC One and TNT Sports 1.
You can also stream the match via the BBC iPlayer app on mobile devices.
Coverage on BBC One starts at 4.45pm and is scheduled to finish at 7.30pm. The match could go to extra time and penalties if the two teams are level.
How can I listen to commentary?
The club’s official channel, Saints Play, will provide audio commentary of the game for a fee. A monthly audio pass is currently priced at £5.
Local listeners can catch radio commentary by BBC Radio Solent on DAB or 96.1MHz. BBC Radio 5 Live and talkSPORT are available nationally.
Can I follow the game on the Daily Echo?
As always, we will run a live blog from Wembley, offering updates and filling you in on everything that happens before, during, and after the game.