West Ham’s hopes of Premier League survival are boosted by the return of Crysencio Summerville, who missed last weekend’s FA Cup quarter-final defeat to Leeds United through injury.
The 24-year-old is one of six changes for the Hammers, with Mads Hermansen, Konstantinos Mavropanos, Tomas Soucek, Pablo and Valentin Castellanos also coming into the starting XI.
Callum Wilson and Jean-Clair Tdibo are both also fit enough to be named on the bench after a spell on the sidelines.
West Ham XI: Hermansen, Walker-Peters, Disasi, Mavropanos, Diouf; Summerville, Soucek, Fernandes, Bowen; Pablo,Castellanos
Subs: Areola, Wilson, Adama, Todibo, Magassa, Wan-Bissaka, Scarles, Potts, Kante
Wolves, meanwhile, are without defender Matt Doherty as they line up for a first Premier League game in 25 days.
Manager Rob Edwards makes one change from the side that managed a 2-2 draw with Brentford on March 16, with Angel Gomes starting in place of Mateus Mane.
Wolves XI: Sa, Mosquera, Bueno, Krejci; Tchatchoua, Andre, J.Gomes, Bueno; Bellegarde, A.Gomes; Armstrong
Subs: Bentley, Wolfe, Hwang, Arokodare, Lima, R.Gomes, Toti, Mane, Edozie