The crackdown forms part of ongoing efforts to tackle repeat retail crime under Operation Predict, which targets known offenders through a combination of business engagement, evidence gathering and enforcement action.
Police said 43 individuals have been charged with offences under the operation.
Twenty-two of those have received custodial sentences amounting to a total of 10 years and four months behind bars, and 11 have been handed criminal behaviour orders.
These orders can offer a range of restrictions which can curb reoffending.
The force said it is working to ensure its targeted approach in the city centre does not simply push offenders into other areas of Southampton by working together across the city.
Chief Inspector Charlie Ilderton, deputy district commander for Southampton, said: “We are trying to take every opportunity available to work in a coordinated and efficient way to tackle repeat offenders across the city.
“Bringing this approach to all our sectors means our persistent offenders cannot simply move elsewhere in the city to try and avoid attention, and the results speak for themselves.
“We know the commitment and relentless focus from our teams is making a genuine difference every day.”
Police on patrol in Southampton city centre (Image: Hampshire police)
Operation Predict involves regular patrols by city centre officers, close collaboration with businesses, and support from the council and GO! Southampton.
Officers identify and target repeat offenders, gather evidence, and build cases to support prosecution.
They are also exploring new methods to prevent and reduce shoplifting.
A spokesperson for Hampshire police added: “Not only does shoplifting have an impact on all of us as consumers, we often see threats and violence towards staff at stores which is completely unacceptable.”
The force has highlighted the importance of partnership working, with support from local businesses, the council and GO! Southampton.