Arsenal make three changes from the 4-0 win over Leeds on Saturday as they look to protect their 3-2 lead in the second leg at Emirates Stadium.
Injury doubt Bukayo Saka is not involved, neither is captain Martin Odegaard.
Kepa Arrizabalaga retains his place as the cup goalkeeper in place of David Raya.
Arsenal XI: Arrizabalaga, Timber, Saliba, Gabriel, Hincapie, Rice, Zubimendi, Eze, Madueke, Martinelli, Gyokeres.
Subs: Raya, Mosquera, White, Jesus, Norgaard, Trossard, Havertz, Calafiori, Lewis-Skelly.
Chelsea make four changes from the 3-2 comeback win over West Ham on Saturday.
Liam Rosenior plays a back five for the first time as Chelsea manager in a team with wing-backs instead of wingers.
Estevao Willian makes the bench having been in Brazil on compassionate leave over the weekend.
Chelsea XI: Sanchez, Gusto, Fofana, Chalobah, Hato, Cucurella, Caicedo, Andrey Santos, Enzo, Delap, Joao Pedro.
Subs: Sharman-Lowe, Acheampong, Badiashile, Holland, Palmer, Estevao, Garnacho, Guiu, Mheuka.