Cole Palmer and Reece James return from minor injuries to start for Chelsea.
Liam Delap is also back on the bench after a spell out with illness but Malo Gusto and Jamie Gittens remain unavailable.
New manager Liam Rosenior makes five changes from the team which lost 3-2 at home to Arsenal in the first leg of the Carabao Cup semi-final.
Chelsea XI: Sanchez, James, Tosin, Chalobah, Cucurella, Caicedo, Fernandez, Neto, Palmer, Garnacho, Joao Pedro.
Subs: Jorgensen, Fofana, Acheampong, Badiashile, Hato, Andrey Santos, George, Delap, Guiu
Brentford manager Keith Andrews makes eight changes from the 2-0 win at Sheffield Wednesday last week in the FA Cup.
However, midfielder Jordan Henderson remains out for Brentford at Stamford Bridge having had a late fitness test before kick-off.
Dango Ouattara is back from the Africa Cup of Nations and makes the bench.
Brentford XI: Kelleher, Ajer, Collins, Janelt, Kayode, Jensen, Yarmoliuk, Daamsgard, Henry, Schade, Igor Thiago
Subs: Valdimarsson, Hickey, Van Den Berg, Pinnock, Nelson, Ouattara, Lewis-Potter, Donovan, Furo